Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4089

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.08, p 0.838). This receipt's hash covers every field on it, plus the hash of receipt 4088, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4089
    20 Oct 2026, 09:37 UTC

    PCSK9

    dopamine neurons, braak

    predictionPCSK9 in dopamine neurons tracks Braak Lewy-body stage

    registered6a09694ab5f7f8d1

    discovery+0.08 p=0.838 n=9

    replication-0.77 p=0.015 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.08, p 0.838)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6e89699835b63a5a9e5ebbfe…
    follows 0b1fd5df3baf…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4089: PCSK9 in dopamine neurons, braak

power
full sample -0.21 (p 0.408, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.310, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.140, n 18). could be the mix.
skeptic
leave-one-out range -0.30 to -0.11, sign flips 0; without severely affected donors -0.21 (p 0.408, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PCSK9 in dopamine neurons.

case closed: nothing better to follow up.