Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4078

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.41, p 0.269). This receipt's hash covers every field on it, plus the hash of receipt 4077, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4078
    20 Oct 2026, 09:23 UTC

    TRIM67

    oligodendrocytes, braak

    predictionTRIM67 in oligodendrocytes tracks Braak Lewy-body stage

    registeredfe699af75e42b77f

    discovery-0.41 p=0.269 n=9

    replication+0.04 p=0.927 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.41, p 0.269)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4ef5e3b1a6793868a0e08221…
    follows fbf86ba12677…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4078: TRIM67 in oligodendrocytes, braak

power
full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.00 (p 0.997, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.26 (p 0.294, n 18). could be the mix.
skeptic
leave-one-out range -0.08 to +0.14, sign flips 8; without severely affected donors +0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TRIM67 in oligodendrocytes.

case closed: nothing better to follow up.