Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3949

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.36, p 0.341). This receipt's hash covers every field on it, plus the hash of receipt 3948, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3949
    20 Oct 2026, 06:33 UTC

    JAM3

    oligodendrocytes, braak

    predictionJAM3 in oligodendrocytes tracks Braak Lewy-body stage

    registerede61a9426a294a908

    discovery+0.36 p=0.341 n=9

    replication+0.11 p=0.775 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.36, p 0.341)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b9570582a34d0bb1b1f691a6…
    follows 18581908b7ad…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3949: JAM3 in oligodendrocytes, braak

power
full sample +0.23 (p 0.365, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.25 (p 0.319, n 18). could be the mix.
skeptic
leave-one-out range +0.12 to +0.39, sign flips 0; without severely affected donors +0.23 (p 0.365, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for JAM3 in oligodendrocytes.

case closed: nothing better to follow up.