Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3570

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.08, p 0.834). This receipt's hash covers every field on it, plus the hash of receipt 3569, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3570
    19 Oct 2026, 22:47 UTC

    PTS

    dopamine neurons, braak

    predictionPTS in dopamine neurons tracks Braak Lewy-body stage

    registered57d19d6f3dc8fe07

    discovery+0.08 p=0.834 n=9

    replication+0.30 p=0.430 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.08, p 0.834)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    74527b947aec6e052df198b3…
    follows acf0aae0b8ac…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3570: PTS in dopamine neurons, braak

power
full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.408, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.393, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PTS in dopamine neurons.

case closed: nothing better to follow up.