Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3367

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.61, p 0.078). This receipt's hash covers every field on it, plus the hash of receipt 3366, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3367
    19 Oct 2026, 18:23 UTC

    TRIM3

    dopamine neurons, braak

    predictionTRIM3 in dopamine neurons tracks Braak Lewy-body stage

    registered8bcd0e8b0ccda760

    discovery-0.61 p=0.078 n=9

    replication-0.23 p=0.551 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.61, p 0.078)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    af1a8621ee1bd05665e1f03b…
    follows 2d503fac1496…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3367: TRIM3 in dopamine neurons, braak

power
full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.011, n 18). not the mix.
skeptic
leave-one-out range -0.49 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
cell type
strongest in microglia: -0.59 (p 0.0096, n 18) vs -0.40 in dopamine neurons. proposing microglia.
axis
no measure beats "tracks Braak Lewy-body stage" for TRIM3 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TRIM3 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.28 p 0.328 (needs p < 5.6e-4)