Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3225

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.06, p 0.877). This receipt's hash covers every field on it, plus the hash of receipt 3224, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3225
    19 Oct 2026, 15:13 UTC

    DICER1

    oligodendrocytes, braak

    predictionDICER1 in oligodendrocytes tracks Braak Lewy-body stage

    registered6ebdc018c6dd844e

    discovery-0.06 p=0.877 n=9

    replication+0.87 p=0.0025 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.06, p 0.877)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4cd729fd813f72bf3c07172e…
    follows 77c564ef45e4…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3225: DICER1 in oligodendrocytes, braak

power
full sample +0.43 (p 0.075, n 18), 95% CI -0.05 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.43 (p 0.072, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.67 (p 0.0022, n 18). not the mix.
skeptic
leave-one-out range +0.35 to +0.58, sign flips 0; without severely affected donors +0.43 (p 0.075, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DICER1 in oligodendrocytes.

case closed: nothing better to follow up.