Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3189

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.49, p 0.181). This receipt's hash covers every field on it, plus the hash of receipt 3188, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3189
    19 Oct 2026, 14:23 UTC

    PDE4A

    dopamine neurons, braak

    predictionPDE4A in dopamine neurons tracks Braak Lewy-body stage

    registered326fc5b173bb8abf

    discovery-0.49 p=0.181 n=9

    replication-0.51 p=0.160 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.49, p 0.181)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7c8360c931124dd073e68c9e…
    follows 83b95a4a43b5…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3189: PDE4A in dopamine neurons, braak

power
full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.39 (p 0.105, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.046, n 18). not the mix.
skeptic
leave-one-out range -0.53 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDE4A in dopamine neurons.

case closed: nothing better to follow up.