Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2791

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.03, p 0.944). This receipt's hash covers every field on it, plus the hash of receipt 2790, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2791
    19 Oct 2026, 05:16 UTC

    MAP3K13

    dopamine neurons, braak

    predictionMAP3K13 in dopamine neurons tracks Braak Lewy-body stage

    registereda90a5b7d33dfdcae

    discovery-0.03 p=0.944 n=9

    replication+0.28 p=0.472 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.03, p 0.944)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    804ae90caef191e61952f56d…
    follows 7ef63f0563d6…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2791: MAP3K13 in dopamine neurons, braak

power
full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.413, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.476, n 18). could be the mix.
skeptic
leave-one-out range +0.04 to +0.28, sign flips 0; without severely affected donors +0.12 (p 0.627, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MAP3K13 in dopamine neurons.

case closed: nothing better to follow up.