Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2534

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.21, p 0.586). This receipt's hash covers every field on it, plus the hash of receipt 2533, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2534
    19 Oct 2026, 00:10 UTC

    TRPV4

    dopamine neurons, braak

    predictionTRPV4 in dopamine neurons tracks Braak Lewy-body stage

    registered2da1939623426d14

    discovery-0.21 p=0.586 n=9

    replication-0.66 p=0.054 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.21, p 0.586)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c949d178e5f656712364a361…
    follows 6c4de5e06a5f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2534: TRPV4 in dopamine neurons, braak

power
full sample -0.47 (p 0.051, n 18), 95% CI -0.77 to +0.00. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.64 (p 0.0045, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.051, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TRPV4 in dopamine neurons.

case closed: nothing better to follow up.