Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2414

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.13, p 0.732). This receipt's hash covers every field on it, plus the hash of receipt 2413, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2414
    18 Oct 2026, 21:33 UTC

    CYBB

    microglia, braak

    predictionCYBB in microglia tracks Braak Lewy-body stage

    registeredb63000145aaf1183

    discovery-0.13 p=0.732 n=9

    replication-0.21 p=0.583 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.13, p 0.732)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    dc7205795b803e8943136ecb…
    follows 1a11c35fecd1…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2414: CYBB in microglia, braak

power
full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
skeptic
leave-one-out range -0.42 to -0.13, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYBB in microglia.

case closed: nothing better to follow up.