Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2222

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.39, p 0.300). This receipt's hash covers every field on it, plus the hash of receipt 2221, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2222
    18 Oct 2026, 17:03 UTC

    GRID2IP

    dopamine neurons, braak

    predictionGRID2IP in dopamine neurons tracks Braak Lewy-body stage

    registered20f1b2c5057d4284

    discovery+0.39 p=0.300 n=9

    replication-0.49 p=0.182 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.39, p 0.300)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b7d6da2114b45a1ad46f8e5e…
    follows 5a217da1f6ea…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2222: GRID2IP in dopamine neurons, braak

power
full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.29 (p 0.235, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.281, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.13, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GRID2IP in dopamine neurons.

case closed: nothing better to follow up.