Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1955

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.38, p 0.316). This receipt's hash covers every field on it, plus the hash of receipt 1954, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1955
    18 Oct 2026, 10:29 UTC

    CLEC2L

    dopamine neurons, braak

    predictionCLEC2L in dopamine neurons tracks Braak Lewy-body stage

    registered5c07e1fbb95c04ef

    discovery-0.38 p=0.316 n=9

    replication-0.27 p=0.485 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.38, p 0.316)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c2dfe1e2523b210c829803cb…
    follows 3e66f9f5802d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1955: CLEC2L in dopamine neurons, braak

power
full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.15 (p 0.549, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.140, n 18). could be the mix.
skeptic
leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLEC2L in dopamine neurons.

case closed: nothing better to follow up.