Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1458

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.24, p 0.529). This receipt's hash covers every field on it, plus the hash of receipt 1457, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1458
    17 Oct 2026, 23:15 UTC

    SLC12A2

    oligodendrocytes, braak

    predictionSLC12A2 in oligodendrocytes tracks Braak Lewy-body stage

    registered8bb353688ad790ba

    discovery+0.24 p=0.529 n=9

    replication+0.27 p=0.487 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.24, p 0.529)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    25ce4e284c8cbe7ae9f9d3c9…
    follows 308cf7df85b8…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1458: SLC12A2 in oligodendrocytes, braak

power
full sample +0.19 (p 0.450, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.25 (p 0.310, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.32, sign flips 0; without severely affected donors +0.19 (p 0.450, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC12A2 in oligodendrocytes.

case closed: nothing better to follow up.