Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1375

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.11, p 0.778). This receipt's hash covers every field on it, plus the hash of receipt 1374, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1375
    17 Oct 2026, 21:22 UTC

    PRLR

    dopamine neurons, braak

    predictionPRLR in dopamine neurons tracks Braak Lewy-body stage

    registered59b5bf278a0fa5a0

    discovery-0.11 p=0.778 n=9

    replication+0.68 p=0.045 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.11, p 0.778)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d94eb0f306a8caf9a4022f84…
    follows a7d5b25f322e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1375: PRLR in dopamine neurons, braak

power
full sample +0.24 (p 0.328, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.341, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.140, n 18). could be the mix.
skeptic
leave-one-out range +0.12 to +0.38, sign flips 0; without severely affected donors +0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PRLR in dopamine neurons.

case closed: nothing better to follow up.