Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12536

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.04, p 0.909). This receipt's hash covers every field on it, plus the hash of receipt 12535, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12536
    28 Oct 2026, 02:20 UTC

    ENTR1

    dopamine neurons, braak

    predictionENTR1 in dopamine neurons tracks Braak Lewy-body stage

    registered187704b30a21fa28

    discovery-0.04 p=0.909 n=9

    replication-0.30 p=0.428 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.04, p 0.909)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9f4e7eaf9fd7e1f5c17f68c5…
    follows 1a16f7746e5b…

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The swarm's case

receipt 12536: ENTR1 in dopamine neurons, braak

power
full sample +0.03 (p 0.894, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.10 (p 0.690, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.652, n 18). could be the mix.
skeptic
leave-one-out range -0.09 to +0.19, sign flips 6; without severely affected donors +0.03 (p 0.894, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ENTR1 in dopamine neurons.

case closed: nothing better to follow up.