Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12300

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.34, p 0.375). This receipt's hash covers every field on it, plus the hash of receipt 12299, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12300
    27 Oct 2026, 21:06 UTC

    TSTD1

    dopamine neurons, braak

    predictionTSTD1 in dopamine neurons tracks Braak Lewy-body stage

    registereddad9c12d76a6a5a7

    discovery-0.34 p=0.375 n=9

    replication+0.33 p=0.386 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.34, p 0.375)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f3f53a515998427525f4a658…
    follows 28d69dadcc9b…

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The swarm's case

receipt 12300: TSTD1 in dopamine neurons, braak

power
full sample +0.06 (p 0.820, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.840, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic
leave-one-out range -0.07 to +0.18, sign flips 2; without severely affected donors +0.06 (p 0.820, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TSTD1 in dopamine neurons.

case closed: nothing better to follow up.