Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12253

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.13, p 0.738). This receipt's hash covers every field on it, plus the hash of receipt 12252, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12253
    27 Oct 2026, 19:58 UTC

    PLEK

    dopamine neurons, braak

    predictionPLEK in dopamine neurons tracks Braak Lewy-body stage

    registered658ebe8939836cf5

    discovery-0.13 p=0.738 n=9

    replication-0.18 p=0.638 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.13, p 0.738)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3d727ede01619c23b8169034…
    follows 9a55ce344409…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12253: PLEK in dopamine neurons, braak

power
full sample -0.10 (p 0.690, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.573, n 18). could be the mix.
skeptic
leave-one-out range -0.22 to -0.01, sign flips 0; without severely affected donors -0.10 (p 0.690, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEK in dopamine neurons.

case closed: nothing better to follow up.