Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12235

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.29, p 0.443). This receipt's hash covers every field on it, plus the hash of receipt 12234, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12235
    27 Oct 2026, 19:33 UTC

    ATP1B1

    dopamine neurons, braak

    predictionATP1B1 in dopamine neurons tracks Braak Lewy-body stage

    registered118925b76ce7c6aa

    discovery-0.29 p=0.443 n=9

    replication+0.33 p=0.385 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.29, p 0.443)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    97f58d2ddf9d595b974761a7…
    follows fb1f767c4b2c…

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The swarm's case

receipt 12235: ATP1B1 in dopamine neurons, braak

power
full sample +0.01 (p 0.969, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.854, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.834, n 18). could be the mix.
skeptic
leave-one-out range -0.09 to +0.16, sign flips 9; without severely affected donors +0.01 (p 0.969, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ATP1B1 in dopamine neurons.

case closed: nothing better to follow up.