Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1204

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.33, p 0.386). This receipt's hash covers every field on it, plus the hash of receipt 1203, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1204
    17 Oct 2026, 17:14 UTC

    COQ5

    dopamine neurons, braak

    predictionCOQ5 in dopamine neurons tracks Braak Lewy-body stage

    registered267ec586d78836a1

    discovery+0.33 p=0.386 n=9

    replication+0.32 p=0.400 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.33, p 0.386)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f301bf658ba42ccd8e157b00…
    follows 3613f696cabc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1204: COQ5 in dopamine neurons, braak

power
full sample +0.29 (p 0.250, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.243, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.164, n 18). could be the mix.
skeptic
leave-one-out range +0.20 to +0.48, sign flips 0; without severely affected donors +0.29 (p 0.250, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for COQ5 in dopamine neurons.

case closed: nothing better to follow up.