Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1181

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.638). This receipt's hash covers every field on it, plus the hash of receipt 1180, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1181
    17 Oct 2026, 16:38 UTC

    NDUFA3

    dopamine neurons, braak

    predictionNDUFA3 in dopamine neurons tracks Braak Lewy-body stage

    registered562bc183c95b1292

    discovery+0.18 p=0.638 n=9

    replication+0.43 p=0.253 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.638)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    75b7fc5e042f7619e8177a49…
    follows 6de75a0d774e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1181: NDUFA3 in dopamine neurons, braak

power
full sample +0.29 (p 0.250, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.167, n 18). could be the mix.
skeptic
leave-one-out range +0.19 to +0.41, sign flips 0; without severely affected donors +0.29 (p 0.250, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NDUFA3 in dopamine neurons.

case closed: nothing better to follow up.