Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11680

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.30, p 0.426). This receipt's hash covers every field on it, plus the hash of receipt 11679, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11680
    27 Oct 2026, 07:11 UTC

    ITGA6

    dopamine neurons, braak

    predictionITGA6 in dopamine neurons tracks Braak Lewy-body stage

    registeredbf49b8c95f37e712

    discovery-0.30 p=0.426 n=9

    replication+0.26 p=0.499 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.30, p 0.426)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    eadf470dcdd9860eca09269b…
    follows be8e0d49920d…

Covered by the on-chain checkpoint of receipt 11685 (2026-10-27 07:18 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11680: ITGA6 in dopamine neurons, braak

power
full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.962, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.393, n 18). could be the mix.
skeptic
leave-one-out range -0.16 to +0.07, sign flips 4; without severely affected donors -0.04 (p 0.861, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ITGA6 in dopamine neurons.

case closed: nothing better to follow up.