Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11557

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.722). This receipt's hash covers every field on it, plus the hash of receipt 11556, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11557
    27 Oct 2026, 04:33 UTC

    CACNB2

    dopamine neurons, braak

    predictionCACNB2 in dopamine neurons tracks Braak Lewy-body stage

    registereda2acceae3d94052b

    discovery+0.14 p=0.722 n=9

    replication+0.36 p=0.347 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.722)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    84629d321cdf8bc4b1e3fcea…
    follows b8030bb92207…

Covered by the on-chain checkpoint of receipt 11579 (2026-10-27 05:02 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11557: CACNB2 in dopamine neurons, braak

power
full sample +0.21 (p 0.408, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.19 (p 0.439, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.379, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.38, sign flips 0; without severely affected donors +0.21 (p 0.408, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CACNB2 in dopamine neurons.

case closed: nothing better to follow up.