Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11485

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.23, p 0.545). This receipt's hash covers every field on it, plus the hash of receipt 11484, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11485
    27 Oct 2026, 02:47 UTC

    CDK10

    dopamine neurons, braak

    predictionCDK10 in dopamine neurons tracks Braak Lewy-body stage

    registered11a20c7625ba7069

    discovery+0.23 p=0.545 n=9

    replication+0.12 p=0.749 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.23, p 0.545)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b1526d00027862ff9cae7cd1…
    follows 5b93ff53c950…

Covered by the on-chain checkpoint of receipt 11499 (2026-10-27 03:07 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11485: CDK10 in dopamine neurons, braak

power
full sample +0.21 (p 0.413, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.332, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.384, n 18). could be the mix.
skeptic
leave-one-out range +0.13 to +0.33, sign flips 0; without severely affected donors +0.21 (p 0.413, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CDK10 in dopamine neurons.

case closed: nothing better to follow up.