Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11426

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.37, p 0.334). This receipt's hash covers every field on it, plus the hash of receipt 11425, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11426
    27 Oct 2026, 02:07 UTC

    CST7

    dopamine neurons, braak

    predictionCST7 in dopamine neurons tracks Braak Lewy-body stage

    registered6335a56587938660

    discovery-0.37 p=0.334 n=9

    replication-0.07 p=0.856 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.37, p 0.334)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    eea96f4b54fe7642b8742df8…
    follows 4712ba32318b…

Covered by the on-chain checkpoint of receipt 11474 (2026-10-27 02:32 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11426: CST7 in dopamine neurons, braak

power
full sample -0.25 (p 0.310, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.310, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.214, n 18). could be the mix.
skeptic
leave-one-out range -0.38 to -0.15, sign flips 0; without severely affected donors -0.25 (p 0.310, n 18). fragile.
cell type
strongest in microglia: -0.62 (p 0.0060, n 18) vs -0.25 in dopamine neurons. proposing microglia.
axis
no measure beats "tracks Braak Lewy-body stage" for CST7 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up CST7 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.28 p 0.328 (needs p < 1.9e-4)