Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11295

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.31, p 0.414). This receipt's hash covers every field on it, plus the hash of receipt 11294, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11295
    26 Oct 2026, 23:12 UTC

    IMPDH1

    dopamine neurons, braak

    predictionIMPDH1 in dopamine neurons tracks Braak Lewy-body stage

    registeredf75709e5a4cd25eb

    discovery-0.31 p=0.414 n=9

    replication-0.17 p=0.654 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.31, p 0.414)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8cb43a451f6246be3ca2635b…
    follows 9b8d153a2fb3…

Covered by the on-chain checkpoint of receipt 11319 (2026-10-26 23:45 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11295: IMPDH1 in dopamine neurons, braak

power
full sample -0.28 (p 0.269, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.052, n 18). could be the mix.
skeptic
leave-one-out range -0.39 to -0.17, sign flips 0; without severely affected donors -0.28 (p 0.269, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IMPDH1 in dopamine neurons.

case closed: nothing better to follow up.