Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11291

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.43, p 0.244). This receipt's hash covers every field on it, plus the hash of receipt 11290, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11291
    26 Oct 2026, 23:07 UTC

    RPS21

    dopamine neurons, braak

    predictionRPS21 in dopamine neurons tracks Braak Lewy-body stage

    registered59b12a72f0328918

    discovery+0.43 p=0.244 n=9

    replication+0.17 p=0.663 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.43, p 0.244)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c1bb5b81cf93f88576feca65…
    follows 4dfa45a2e219…

Covered by the on-chain checkpoint of receipt 11292 (2026-10-26 23:10 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11291: RPS21 in dopamine neurons, braak

power
full sample +0.31 (p 0.211, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.34 (p 0.173, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.188, n 18). could be the mix.
skeptic
leave-one-out range +0.22 to +0.42, sign flips 0; without severely affected donors +0.31 (p 0.211, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RPS21 in dopamine neurons.

case closed: nothing better to follow up.