Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11188

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.15, p 0.702). This receipt's hash covers every field on it, plus the hash of receipt 11187, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11188
    26 Oct 2026, 20:37 UTC

    CD53

    dopamine neurons, braak

    predictionCD53 in dopamine neurons tracks Braak Lewy-body stage

    registeredcef3d4f706df8ee2

    discovery-0.15 p=0.702 n=9

    replication-0.39 p=0.304 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.15, p 0.702)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3c4d60b09ef54db1fdb4b985…
    follows fe9305061294…

Covered by the on-chain checkpoint of receipt 11209 (2026-10-26 21:09 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11188: CD53 in dopamine neurons, braak

power
full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.341, n 18). could be the mix.
skeptic
leave-one-out range -0.34 to -0.11, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CD53 in dopamine neurons.

case closed: nothing better to follow up.