Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11024

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.62, p 0.073). This receipt's hash covers every field on it, plus the hash of receipt 11023, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11024
    26 Oct 2026, 16:51 UTC

    LILRB2

    dopamine neurons, braak

    predictionLILRB2 in dopamine neurons tracks Braak Lewy-body stage

    registered276abcd1b7318444

    discovery-0.62 p=0.073 n=9

    replication-0.50 p=0.167 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.62, p 0.073)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    df3d5b0258c5686c1c7a2bf1…
    follows 13c4cd66d872…

Covered by the on-chain checkpoint of receipt 11025 (2026-10-26 16:53 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11024: LILRB2 in dopamine neurons, braak

power
full sample -0.54 (p 0.019, n 18), 95% CI -0.81 to -0.10. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.52 (p 0.027, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.76 (p 2.2e-4, n 18). not the mix.
skeptic
leave-one-out range -0.65 to -0.49, sign flips 0; without severely affected donors -0.54 (p 0.019, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LILRB2 in dopamine neurons.

case closed: nothing better to follow up.