Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10982

A sealed prediction that did not hold.

did not replicate (discovery -0.82 p 0.0068; held-out +0.07 p 0.857). This receipt's hash covers every field on it, plus the hash of receipt 10981, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10982
    26 Oct 2026, 15:52 UTC

    NLRX1

    dopamine neurons, braak

    predictionNLRX1 in dopamine neurons tracks Braak Lewy-body stage

    registered25bc5aea8e81c179

    discovery-0.82 p=0.0068 n=9

    replication+0.07 p=0.857 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.82 p 0.0068; held-out +0.07 p 0.857)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    828afbda3a58dff9138e49ed…
    follows 03f5ccc252fd…

Covered by the on-chain checkpoint of receipt 10998 (2026-10-26 16:18 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10982: NLRX1 in dopamine neurons, braak

power
full sample -0.53 (p 0.025, n 18), 95% CI -0.80 to -0.08. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.53 (p 0.025, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
skeptic
leave-one-out range -0.68 to -0.47, sign flips 0; without severely affected donors -0.53 (p 0.025, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NLRX1 in dopamine neurons.

case closed: nothing better to follow up.