Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10837

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.03, p 0.946). This receipt's hash covers every field on it, plus the hash of receipt 10836, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10837
    26 Oct 2026, 12:28 UTC

    FGF23

    dopamine neurons, braak

    predictionFGF23 in dopamine neurons tracks Braak Lewy-body stage

    registered7f74674f7f6fd719

    discovery-0.03 p=0.946 n=9

    replication+0.19 p=0.623 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.03, p 0.946)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    eb49beefb71488878af50b92…
    follows 6d10db9557b7…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10837: FGF23 in dopamine neurons, braak

power
full sample +0.07 (p 0.794, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.847, n 18). could be the mix.
skeptic
leave-one-out range -0.04 to +0.20, sign flips 3; without severely affected donors +0.07 (p 0.794, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FGF23 in dopamine neurons.

case closed: nothing better to follow up.