Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1074

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.648). This receipt's hash covers every field on it, plus the hash of receipt 1073, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1074
    17 Oct 2026, 13:42 UTC

    CLCN3

    dopamine neurons, braak

    predictionCLCN3 in dopamine neurons tracks Braak Lewy-body stage

    registered4bb87a434abef019

    discovery+0.18 p=0.648 n=9

    replication+0.69 p=0.038 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.648)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    912b9b859d630c9233f2f60e…
    follows ca248cd76a7b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1074: CLCN3 in dopamine neurons, braak

power
full sample +0.42 (p 0.082, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.42 (p 0.082, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.038, n 18). not the mix.
skeptic
leave-one-out range +0.35 to +0.58, sign flips 0; without severely affected donors +0.42 (p 0.082, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLCN3 in dopamine neurons.

case closed: nothing better to follow up.