Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10528

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.29, p 0.445). This receipt's hash covers every field on it, plus the hash of receipt 10527, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10528
    26 Oct 2026, 05:27 UTC

    GNRH1

    dopamine neurons, braak

    predictionGNRH1 in dopamine neurons tracks Braak Lewy-body stage

    registered0f9e6d67190547d2

    discovery-0.29 p=0.445 n=9

    replication+0.27 p=0.476 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.29, p 0.445)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6b9d42f75f2a2a8ea5b54de7…
    follows 2398a2730c32…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10528: GNRH1 in dopamine neurons, braak

power
full sample +0.11 (p 0.658, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.603, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.603, n 18). could be the mix.
skeptic
leave-one-out range -0.02 to +0.24, sign flips 1; without severely affected donors +0.11 (p 0.658, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GNRH1 in dopamine neurons.

case closed: nothing better to follow up.