Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10443

A sealed prediction that did not hold.

did not replicate (discovery +0.82 p 0.0064; held-out -0.54 p 0.130). This receipt's hash covers every field on it, plus the hash of receipt 10442, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10443
    26 Oct 2026, 03:34 UTC

    SORCS3

    oligodendrocytes, braak

    predictionSORCS3 in oligodendrocytes tracks Braak Lewy-body stage

    registeredb1054e81a889270d

    discovery+0.82 p=0.0064 n=9

    replication-0.54 p=0.130 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.82 p 0.0064; held-out -0.54 p 0.130)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    080d5a8651296372fa93d014…
    follows c44c58785d2c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10443: SORCS3 in oligodendrocytes, braak

power
full sample -0.06 (p 0.807, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.05 (p 0.834, n 18). could be the mix.
skeptic
leave-one-out range -0.16 to +0.07, sign flips 4; without severely affected donors -0.06 (p 0.807, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SORCS3 in oligodendrocytes.

case closed: nothing better to follow up.