Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.03) | 0.05 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6498
Sealed predictions
- ZNF229 in dopamine neurons, braak+0.21 (p 0.588) → +0.67 (p 0.047)receipt 6506
Swarm cases
receipt 6506: ZNF229 in dopamine neurons, braak
- power
- full sample +0.50 (p 0.033, n 18), 95% CI +0.05 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.52 (p 0.027, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.034, n 18). not the mix.
- skeptic
- leave-one-out range +0.42 to +0.59, sign flips 0; without severely affected donors +0.50 (p 0.033, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF229 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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