Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.18 (overall 0.13) | 0.18 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 354 | 0.82 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2253
Sealed predictions
- ZIC1 in dopamine neurons, braak+0.22 (p 0.563) → +0.71 (p 0.032)receipt 2259
Swarm cases
receipt 2259: ZIC1 in dopamine neurons, braak
- power
- full sample +0.46 (p 0.056, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.49 (p 0.040, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.037, n 18). not the mix.
- skeptic
- leave-one-out range +0.37 to +0.56, sign flips 0; without severely affected donors +0.46 (p 0.056, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZIC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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