Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.04) | 0.05 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 1,107 | 0.82 |
| pathways Reactome | 8 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 6206
Sealed predictions
- USP7 in dopamine neurons, braak-0.33 (p 0.393) → +0.21 (p 0.586)receipt 6212
Swarm cases
receipt 6212: USP7 in dopamine neurons, braak
- power
- full sample -0.04 (p 0.888, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.10, sign flips 3; without severely affected donors -0.04 (p 0.888, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for USP7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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