parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (24 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 370	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 5334

TWIST2 in dopamine neurons, braak-0.51 (p 0.157) → -0.13 (p 0.732)receipt 5342
TWIST2 in microglia, braak+0.18 (p 0.652) → -0.05 (p 0.894)receipt 5341

receipt 5342: TWIST2 in dopamine neurons, braak

power: full sample -0.40 (p 0.099, n 18), 95% CI -0.73 to +0.08. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.125, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.072, n 18). could be the mix.
skeptic: leave-one-out range -0.52 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.099, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TWIST2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5341: TWIST2 in microglia, braak

power: full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.820, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.01 (p 0.976, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.17, sign flips 4; without severely affected donors +0.07 (p 0.787, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TWIST2 in microglia.

case closed: nothing better to follow up.

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