Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11105
Sealed predictions
- TUSC2 in dopamine neurons, braak+0.41 (p 0.273) → -0.12 (p 0.753)receipt 11111
Swarm cases
receipt 11111: TUSC2 in dopamine neurons, braak
- power
- full sample +0.17 (p 0.509, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.482, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.498, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.34, sign flips 0; without severely affected donors +0.17 (p 0.509, n 18). fragile.
- cell type
- strongest in astrocytes: -0.59 (p 0.0097, n 18) vs +0.17 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TUSC2 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TUSC2 · astrocytes · braak: substantia nigra, an independent cohort: not measured
Receipts
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