Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in müller glia | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8479
Sealed predictions
- TSC22D4 in dopamine neurons, braak-0.34 (p 0.374) → -0.34 (p 0.373)receipt 8487
- TSC22D4 in oligodendrocytes, braak+0.00 (p 1.000) → +0.00 (p 1.000)receipt 8486
Swarm cases
receipt 8487: TSC22D4 in dopamine neurons, braak
- power
- full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.35 (p 0.150, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.25, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TSC22D4 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8486: TSC22D4 in oligodendrocytes, braak
- power
- full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.935, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.12, sign flips 8; without severely affected donors +0.00 (p 0.990, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TSC22D4 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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