Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (goblet cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: grc-17536, butamben, menthol +1 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 11 Parkinson's papers of NaN | 0.67 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3412
Sealed predictions
- TRPA1 in dopamine neurons, braak+0.02 (p 0.964) → -0.17 (p 0.671)receipt 3419
Swarm cases
receipt 3419: TRPA1 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.615, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.633, n 18). could be the mix.
- skeptic
- leave-one-out range -0.26 to -0.03, sign flips 0; without severely affected donors -0.13 (p 0.615, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRPA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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