Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 668 | 0.69 |
| pathways Reactome | 4 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 7892
Sealed predictions
- TRIM28 in dopamine neurons, braak-0.34 (p 0.378) → -0.64 (p 0.063)receipt 7899
Swarm cases
receipt 7899: TRIM28 in dopamine neurons, braak
- power
- full sample -0.54 (p 0.020, n 18), 95% CI -0.81 to -0.10. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.56 (p 0.015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.010, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.47, sign flips 0; without severely affected donors -0.54 (p 0.020, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM28 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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