Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.14 (overall 0.08) | 0.14 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3127
Sealed predictions
- TPRA1 in dopamine neurons, braak-0.05 (p 0.891) → -0.22 (p 0.567)receipt 3135
Swarm cases
receipt 3135: TPRA1 in dopamine neurons, braak
- power
- full sample -0.19 (p 0.455, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.337, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.328, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.08, sign flips 0; without severely affected donors -0.19 (p 0.455, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.64 (p 0.0039, n 18) vs -0.19 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TPRA1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TPRA1 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.25 p 0.374 (needs p < 6.0e-4)
Receipts
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