parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in t-cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 12601

TNFSF8 in dopamine neurons, braak-0.48 (p 0.188) → -0.24 (p 0.530)receipt 12610
TNFSF8 in microglia, braak+0.03 (p 0.947) → -0.60 (p 0.088)receipt 12609

receipt 12610: TNFSF8 in dopamine neurons, braak

power: full sample -0.37 (p 0.127, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.48 (p 0.046, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.66 (p 0.0029, n 18). not the mix.
skeptic: leave-one-out range -0.48 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.127, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TNFSF8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12609: TNFSF8 in microglia, braak

power: full sample -0.28 (p 0.254, n 18), 95% CI -0.66 to +0.21. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.23 (p 0.360, n 18). could be the mix.
skeptic: leave-one-out range -0.44 to -0.18, sign flips 0; without severely affected donors -0.28 (p 0.254, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TNFSF8 in microglia.

case closed: nothing better to follow up.

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