Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in tuft cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 54 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9442
Sealed predictions
- TMEM63A in dopamine neurons, braak-0.31 (p 0.414) → -0.14 (p 0.723)receipt 9450
- TMEM63A in oligodendrocytes, braak+0.10 (p 0.802) → -0.60 (p 0.086)receipt 9449
Swarm cases
receipt 9450: TMEM63A in dopamine neurons, braak
- power
- full sample -0.16 (p 0.515, n 18), 95% CI -0.59 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.22 (p 0.389, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.413, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.515, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM63A in dopamine neurons.
case closed: nothing better to follow up.
receipt 9449: TMEM63A in oligodendrocytes, braak
- power
- full sample -0.24 (p 0.346, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.221, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.38 (p 0.125, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.13, sign flips 0; without severely affected donors -0.24 (p 0.346, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM63A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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