Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 10 Parkinson's trials, 1 stopped | 0.92 |
| literature PubMed | 437 Parkinson's papers of 86,292 | 0.20 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7226
Sealed predictions
- TG in dopamine neurons, braak-0.17 (p 0.666) → -0.29 (p 0.449)receipt 7235
Swarm cases
receipt 7235: TG in dopamine neurons, braak
- power
- full sample -0.22 (p 0.379, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.346, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.125, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.379, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TG in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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