Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.19 (overall 0.13) | 0.19 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 97 Parkinson's papers of 2,909 | 0.40 |
| pathways Reactome | 3 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 2270
Sealed predictions
- TFAM in dopamine neurons, braak+0.12 (p 0.749) → +0.23 (p 0.551)receipt 2278
Swarm cases
receipt 2278: TFAM in dopamine neurons, braak
- power
- full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.748, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.671, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.16, sign flips 5; without severely affected donors +0.04 (p 0.861, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TFAM in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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