Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | 6 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 96 Parkinson's papers of 18,256 | 0.40 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5589
Sealed predictions
- TAT in dopamine neurons, braak+0.79 (p 0.012) → +0.31 (p 0.414)receipt 5596
Swarm cases
receipt 5596: TAT in dopamine neurons, braak
- power
- full sample +0.47 (p 0.051, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.051, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.051, n 18). could be the mix.
- skeptic
- leave-one-out range +0.41 to +0.65, sign flips 0; without severely affected donors +0.47 (p 0.051, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TAT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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