parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.22 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in platelets	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 995	0.79
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 1912

receipt 1920: TAL1 in dopamine neurons, braak

power: full sample -0.34 (p 0.173, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0057, n 18). not the mix.
skeptic: leave-one-out range -0.50 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.173, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TAL1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1919: TAL1 in microglia, braak

power: full sample +0.08 (p 0.767, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.13 (p 0.597, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
skeptic: leave-one-out range -0.05 to +0.24, sign flips 4; without severely affected donors +0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TAL1 in microglia.

case closed: nothing better to follow up.

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