Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.30 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 80 Parkinson's papers of 421 | 0.42 |
| pathways Reactome | 10 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 1303
Sealed predictions
- TAF1 in dopamine neurons, braak-0.20 (p 0.599) → +0.34 (p 0.373)receipt 1311
Swarm cases
receipt 1311: TAF1 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.439, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.23, sign flips 4; without severely affected donors +0.07 (p 0.787, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TAF1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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