Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.04) | 0.05 |
| cell type Human Protein Atlas | cell type enriched outside the brain (pancreatic acinar cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 600 | 0.71 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6128
Sealed predictions
- TAC1 in dopamine neurons, braak+0.16 (p 0.685) → +0.11 (p 0.775)receipt 6135
Swarm cases
receipt 6135: TAC1 in dopamine neurons, braak
- power
- full sample +0.19 (p 0.455, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.27 (p 0.285, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.26 (p 0.306, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.36, sign flips 0; without severely affected donors +0.19 (p 0.455, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TAC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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